Predictably adding to the end of where will have an impact on the meaning of its root. But unlike disinterest and disinterest, in the case where where is needed (and vice versa), you can't really escape the usage without confuse your audience.

Due to the universality and versatility of the word where, English speakers generally can use it correctly without much thinking. If you are asking about the location of the bathroom, you might not accidentally say: "Where is the bathroom?" If you are talking about location at all, then the term you want is almost certainly "location."

So where should you use while? As Grammarist explained, while is before the clause, you are trying to associate it with a contrasting independent clause. If this is a bit too jargon to make any sense, this example should help. Suppose you start with this independent clause: we used to go clubbing on Saturday night. Like all independent clauses, it is a complete sentence in itself. But maybe you want to elaborate by explaining what you look like on Saturday night now. Because what you did in the past will be contrasted with what you do now, and you can link the two together:

We used to go clubbing on Saturday night, but now we stay at home and party to see Doctor Who.

Rather than the only conjunction that can complete this type of clause union-while, although, even but can also work (although you may want to reorder to make the sentence flow better).

To make this more confusing, there is also a history used to introduce legal documents in a way that basically means "consideration". For the contract, this introductory part—mainly explaining the purpose of the document—is called the recital; for the constitution, it is the preamble. In fact, in the past, it was common to start legal documents with while. People have just started to use while as a noun to denote a preamble. In the next casual conversation about the Constitution, please feel free to try to bring this trend back.